Article
Alzheimer's disease: molecular concepts and therapeutic targets.
Die Naturwissenschaften - 1 Jun 2001
Fassbender K, Masters C, Beyreuther K
Abstract excerpt
The beta amyloid peptide is the major component of the neuritic plaques, the characteristic lesions in Alzheimer's disease. Mutations in three genes (APP, PS-1, and PS-2) cause familial Alzheimer's disease by alteration of the rate of generation of amyloid peptide or the length of this peptide. However, in the 90% non-familial cases, other factors play a major pathogenetic role. These include the apolipoprotein E...
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