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Article

Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase.

The Journal of biological chemistry - 27 Mar 2009

Dietzel Uwe, Kuper Jochen, Doebbler Jennifer A, Schulte Antje, Truglio James J, Leimkühler Silke, Kisker Caroline

Abstract excerpt

Rhodobacter capsulatus xanthine dehydrogenase (XDH) is an (alphabeta)(2) heterotetrameric cytoplasmic enzyme that resembles eukaryotic xanthine oxidoreductases in respect to both amino acid sequence and structural fold. To obtain a detailed understanding of the mechanism of substrate and inhibitor binding at the active site, we solved crystal structures of R. capsulatus XDH in the presence of its substrates...

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Identifiers

PMID: 19109249
DOI: 10.1074/jbc.M808114200
PMCID: PMC2659235

Genes

XDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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