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Article

The genetic variant A of human alpha 1-acid glycoprotein limits the blood to brain transfer of drugs it binds.

Life sciences - 1 Jan 1998

Jolliet-Riant P, Boukef M F, Duché J C, Simon N, Tillement J P

Abstract excerpt

The objective of this work was to check the effects of alpha-1 acid glycoprotein (AAG) and of its components, A and F1/S genetic variants, on the brain transfer of drugs they bind in plasma. The relevant extractions of six basic drugs, highly bound to AAG, were measured. We chose three drugs sele...

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PMID: 9570346
DOI: 10.1016/s0024-3205(98)00061-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9570346-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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