Binding of d-methadone, l-methadone, and dl-methadone to proteins in plasma of healthy volunteers: role of the variants of alpha 1-acid glycoprotein.

doi:10.1038/clpt.1990.37

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Article

Binding of d-methadone, l-methadone, and dl-methadone to proteins in plasma of healthy volunteers: role of the variants of alpha 1-acid glycoprotein.

Clinical pharmacology and therapeutics - 1 Mar 1990

Eap C B, Cuendet C, Baumann P

Abstract excerpt

The plasma concentrations of alpha 1-acid glycoprotein (AAG), albumin, triglycerides, cholesterol, and total proteins, as well as the plasma binding of racemic, d-methadone, and l-methadone were measured in 45 healthy subjects. The AAG phenotypes and the concentrations of AAG variants were also d...

Topics

Adult
Blood Proteins
Cholesterol
Female
Humans
Male
Methadone
Middle Aged
Orosomucoid
Phenotype
Protein Binding
Regression Analysis
Serum Albumin
Stereoisomerism
Triglycerides

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