Article
Specific autoantibody profiles and disease subgroups correlate with circulating micro-RNA in systemic sclerosis.
Rheumatology (Oxford, England) - 1 Nov 2015
Wuttge Dirk M, Carlsen Anting Liu, Teku Gabriel, Steen Samantha O, Wildt Marie, Vihinen Mauno, Hesselstrand Roger, Heegaard Niels H H
Abstract excerpt
OBJECTIVE: To evaluate the expression profiles of cell-free plasma miRNAs in SSc and to characterize their correlation with disease subgroups (lcSSc and dcSSc) and with autoantibody profiles. METHODS: Using quantitative RT-PCR, the abundance of 45 mature miRNAs in plasma was determined in 95 patients (lcSSc = 63; dcSSc = 32), representing the following autoantibody subgroups: ACA, anti-DNA topoisomerase I,...
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