Article
APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis.
Journal of neurology, neurosurgery, and psychiatry - 1 Mar 2014
Rannikmäe Kristiina, Kalaria Rajesh N, Greenberg Steven M, Chui Helena C, Schmitt Frederick A, Samarasekera Neshika, Al-Shahi Salman Rustam, Sudlow Cathie L M
Abstract excerpt
OBJECTIVES: Cerebral amyloid angiopathy (CAA) is associated with lobar intracerebral haemorrhage (ICH). While only the ε4 allele of the apolipoprotein E (APOE) gene is associated with the presence of CAA, both APOE-ε4 and ε2 are associated with lobar ICH. The generally accepted explanation is that APOE-ε4 promotes vascular amyloid deposition, while APOE-ε2 promotes progression to severe CAA with associated...
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