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Article

A Clue to the Therapy of Neurofibromatosis Type 2

1 Jan 2004

Abstract excerpt

BACKGROUND: Neurofibromatosis type 2 is a group of tumors caused by loss-of-function mutations of a tumor suppressor gene encoding NF2/merlin. Development of chemotherapeutics for this disease, which often threatens the life of young children, has been hampered by a limited information on the signaling function of NF2. NF2 can inhibit Ras-induced malignant transformation. However, the primary (signaling) target...

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PMID: 15000491
DOI: 10.1097/00130404-200401000-00006

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