Interaction of Native and Mutant MecI Repressors with Sequences That Regulate mecA , the Gene Encoding Penicillin Binding Protein 2a in Methicillin-Resistant Staphylococci

Abstract excerpt

Methicillin resistance in staphylococci is mediated by PBP2a, a penicillin binding protein with low affinity for beta-lactam antibiotics. The gene encoding PBP2a, mecA, is transcriptionally regulated in some clinical isolates by mecR1 and mecI, genes divergently transcribed from mecA that encode a signal transducer and repressor, respectively. The biochemical basis of MecI-mediated mecA transcriptional repression...

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