Article
Genomic diversity of mec regulator genes in methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
Epidemiology and infection - 1 Oct 1996
Kobayashi N, Taniguchi K, Kojima K, Urasawa S, Uehara N, Omizu Y, Kishi Y, Yagihashi A, Kurokawa I, Watanabe N
Abstract excerpt
Low-affinity penicillin-binding protein PBP-2a encoded by mecA is closely related to methicillin resistance in staphylococci, and expression of PBP-2a is controlled by regulator elements encoded by mecR1 and mecI which are located adjacent to mecA on the chromosome. Deletion or mutation which occ...
Topics
- Cross Infection
- DNA, Bacterial
- Gene Expression Regulation, Bacterial
- Genetic Variation
- Humans
- Methicillin Resistance
- Point Mutation
- Serotyping
- Staphylococcal Infections
- Staphylococcus aureus
- Staphylococcus epidermidis