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Article

Genotypic relative risks under ordered restriction.

Genetic epidemiology - 1 Jan 1998

Chiano M N, Clayton D G

Abstract excerpt

In mapping diseases of complex aetiology, conventional linkage approaches narrow the location of the disease susceptibility locus to quite a large region so that candidate gene association studies are then necessary to further isolate these genes. However, even in the simplest scenario where the candidate locus is bi-allelic, two statistical tests with various correcting factors have been proposed: a chi-square 1...

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PMID: 9554552
DOI: 10.1002/(SICI)1098-2272(1998)15:2<135::AID-GEPI3>3.0.CO;2-5

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