Article
Decreased physical performance of congenic mice with mismatch between the nuclear and the mitochondrial genome.
Genes & genetic systems - 1 Feb 1998
Nagao Y, Totsuka Y, Atomi Y, Kaneda H, Lindahl K F, Imai H, Yonekawa H
Abstract excerpt
Maternal transmission of mitochondrial DNA (mtDNA) allows us to generate mtDNA congenic strain by repeating backcrosses of female mice to male mice of an inbred strain, which carries different mtDNA haplotype from that of the female progenitor. Since genetic backgrounds of inbred strains commonly used (e.g., C57BL/6J [B6] and BALB/c) are mainly derived from an European subspecies of Mus musculus domesticus,...
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