Article
mtDNA polymorphism and metabolic inhibition affect sperm performance in conplastic mice.
Reproduction (Cambridge, England) - 1 Oct 2017
Tourmente Maximiliano, Hirose Misa, Ibrahim Saleh, Dowling Damian K, Tompkins Daniel M, Roldan Eduardo R S, Gemmell Neil J
Abstract excerpt
Whereas a broad link exists between nucleotide substitutions in the mitochondrial genome (mtDNA) and a range of metabolic pathologies, exploration of the effect of specific mtDNA genotypes is on-going. Mitochondrial DNA mutations are of particular relevance for reproductive traits, since they are expected to have profound effects on male specific processes as a result of the strict maternal inheritance of mtDNA....
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