Article
C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis.
Atherosclerosis - 1 Jan 1998
Schreyer S A, Wilson D L, LeBoeuf R C
Abstract excerpt
Non-insulin-dependent diabetes mellitus (NIDDM) is a major risk factor for the development of atherosclerosis in humans. The development of an animal model that displays accelerated atherosclerosis associated with NIDDM will aid in elucidating the mechanisms that associate these disorders. C57BL/6 mice may provide such a model system. This strain becomes obese, hyperglycemic and insulin resistant when fed a high...
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