NF-κB-dependent inhibition of apoptosis is essential for host cell survival during <i>Rickettsia rickettsii</i> infection

Abstract excerpt

The possibility that bacteria may have evolved strategies to overcome host cell apoptosis was explored by using Rickettsia rickettsii, an obligate intracellular Gram-negative bacteria that is the etiologic agent of Rocky Mountain spotted fever. The vascular endothelial cell, the primary target cell during in vivo infection, exhibits no evidence of apoptosis during natural infection and is maintained for a...

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