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<i>Chlamydia</i> Inhibit Host Cell Apoptosis by Degradation of Proapoptotic BH3-only Proteins

27 Sept 2004

Abstract excerpt

Chlamydia are obligate intracellular bacteria that replicate in a vacuole inside a host cell. Chlamydial infection has been shown to protect the host cell against apoptotic stimuli. This is likely important for the ability of Chlamydia to reproduce in human cells. Here we show that resistance to apoptosis is conveyed by the destruction of the proapoptotic BH3-only proteins Bim/Bod, Puma, and Bad during infection....

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PMID: 15452181
DOI: 10.1084/jem.20040402

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