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Insights into Pathogen Immune Evasion Mechanisms: <i>Anaplasma phagocytophilum</i> Fails to Induce an Apoptosis Differentiation Program in Human Neutrophils

1 May 2005

Abstract excerpt

Polymorphonuclear leukocytes (PMNs or neutrophils) are essential to human innate host defense. However, some bacterial pathogens circumvent destruction by PMNs and thereby cause disease. Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis, survives within PMNs in part by altering normal host cell processes, such as production of reactive oxygen species (ROS) and apoptosis. To investigate the...

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PMID: 15879137
DOI: 10.4049/jimmunol.174.10.6364

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