Article
Human platelet antigen frequencies of platelet donors in the French population determined by polymerase chain reaction with sequence-specific primers.
Pathologie-biologie - 1 Nov 1997
Mérieux Y, Debost M, Bernaud J, Raffin A, Meyer F, Rigal D
Abstract excerpt
To prevent human platelet alloimmunization, Blood Transfusion Centres have to develop a strategy close to the erythrocytes' one. The first step of this strategy is to perform the HPA typing of donors with an accurate method. We applied the PCR-SSP to type 800 platelet donors in the HPA-1 and HPA-5 systems and 350 in the HPA-2 and HPA-3 ones. This study reports the human platelet antigen frequencies of four...
Topics
- Antigens, Human Platelet
- Blood Donors
- DNA Primers
- Ethnology
- France
- Gene Frequency
- Genotype
- Humans
- Phenotype
- Polymerase Chain Reaction