Article
Human platelet antigen genotyping of platelet donors in southern Brazil.
International journal of immunogenetics - 1 Oct 2015
Merzoni J, Fagundes I S, Lunardi L W, Lindenau J D-R, Gil B C, Jobim M, Dias V G, Merzoni L, Sekine L, Onsten T G H, Jobim L F
Abstract excerpt
Human platelet antigens (HPA) are immunogenic structures that result from single nucleotide polymorphisms (SNPs) leading to single amino acid substitutions. This study sought to determine the allele and genotype frequencies of HPA-1, HPA-2, HPA-3, HPA-4, HPA-5 and HPA-15 in platelet donors from the state of Rio Grande do Sul (RS), Brazil, and compare their allele frequencies to those observed in other...
Topics
- Adult
- Antigens
- Blood Donors
- Blood Platelets
- Brazil
- Female
- Gene Frequency
- Genetic Loci
- Genotype
- Genotyping Techniques
- Humans
- Male
- Phylogeny
- Principal Component Analysis