Article
The 185delAG BRCA1 mutation originated before the dispersion of Jews in the diaspora and is not limited to Ashkenazim.
Human molecular genetics - 1 May 1998
Bar-Sade R B, Kruglikova A, Modan B, Gak E, Hirsh-Yechezkel G, Theodor L, Novikov I, Gershoni-Baruch R, Risel S, Papa M Z, Ben-Baruch G, Friedman E
Abstract excerpt
The 185delAG mutation in BRCA1 is detected in Ashkenazi Jews both in familial breast and ovarian cancer and in the general population. All tested Ashkenazi mutation carriers share the same allelic pattern at the BRCA1 locus. Our previous study showed that this 'Ashkenazi' mutation also occurs in...
Topics
- Adult
- Aged
- Alleles
- Breast Neoplasms
- Female
- Genes, BRCA1
- Genetic Carrier Screening
- Genetic Testing
- Germ-Line Mutation
- Humans
- Iran
- Jews
- Middle Aged
- Morocco
- Ovarian Neoplasms
- Sequence Deletion
- Turkey
- Yemen