Could the 185delAG BRCA1 mutation be an ancient Jewish mutation?

Article

Could the 185delAG BRCA1 mutation be an ancient Jewish mutation?

European journal of human genetics : EJHG - 1 Jan 2000

Bar-Sade R B, Theodor L, Gak E, Kruglikova A, Hirsch-Yechezkel G, Modan B, Kuperstein G, Seligsohn U, Rechavi G, Friedman E

Abstract excerpt

A predominant mutation within the BRCA1 predisposition gene, 185delAG, has been detected in about 1% of the Ashkenazi population, considered a high-risk group for breast and ovarian cancers. We examined 639 unrelated healthy Jews of Iraqi extraction, a presumed low-risk group, for the existence o...

Topics

Adult
Aged
Alleles
Breast Neoplasms
Female
Genes, BRCA1
Genetic Markers
Haplotypes
Heterozygote
Humans
Israel
Jews
Male
Middle Aged
Mutation
Risk Factors

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