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Article

Could the 185delAG BRCA1 mutation be an ancient Jewish mutation?

European journal of human genetics : EJHG - 1 Jan 2000

Bar-Sade R B, Theodor L, Gak E, Kruglikova A, Hirsch-Yechezkel G, Modan B, Kuperstein G, Seligsohn U, Rechavi G, Friedman E

Abstract excerpt

A predominant mutation within the BRCA1 predisposition gene, 185delAG, has been detected in about 1% of the Ashkenazi population, considered a high-risk group for breast and ovarian cancers. We examined 639 unrelated healthy Jews of Iraqi extraction, a presumed low-risk group, for the existence of this mutation. Three individuals were identified as 185delAG mutation carriers, and haplotype analysis of the Iraqi...

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Identifiers

PMID: 9450187

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Could the 185delAG BRCA1 mutation be an ancient Jewish mutation?PMID 9450187Read ↗

The 185delAG BRCA1 mutation originated before the dispersion of Jews in the diaspora and is not limited to Ashkenazim.Semantic proximity Read ↗

Germline BRCA1 185delAG mutations in Jewish women with breast cancerSemantic proximity Read ↗

BRCA1:185delAG found in the San Luis Valley probably originated in a Jewish founder.Semantic proximity Read ↗

Haplotype analysis of a BRCA1: 185delAG mutation in a Chilean family supports its Ashkenazi origins.Semantic proximity Read ↗

The BRCA1 Ashkenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies.Semantic proximity Read ↗

Identification of the 185delAG BRCA1 mutation in a Spanish Gypsy population.Semantic proximity Read ↗

Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2.Semantic proximity Read ↗

Three primary malignancies related to BRCA mutation successively occurring in a BRCA1 185delAG mutation carrier.Semantic proximity Read ↗

Haplotype analysis and ancient origin of the BRCA1 c.4035delA Baltic founder mutation.Semantic proximity Read ↗

The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women.Semantic proximity Read ↗

BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and ovarian cancer.Semantic proximity Read ↗

Prevalence of recurring BRCA mutations among Ashkenazi Jewish women with breast cancer.Semantic proximity Read ↗

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