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BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia

5 Dec 2007

Abstract excerpt

Cancer cells acquire disruptions in normal signal transduction pathways and homeostatic mechanisms that would trigger apoptosis in normal cells. These abnormalities include genomic instability, oncogene activation, and growth factor independent proliferation. Therefore, cancer cells likely require a block in apoptosis in order to survive. Overexpression of the antiapoptotic protein BCL-2 provides a block in...

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PMID: 18056841
DOI: 10.1182/blood-2007-06-098012

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