Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Self-diploidization of human haploid parthenogenetic embryos through the Rho pathway regulates endomitosis and failed cytokinesis

20 Jun 2017

Abstract excerpt

A diploid genome is necessary for normal mammalian development, thus haploid parthenogenetic embryos undergo frequent self-diploidization during preimplantation development; however, the underlying mechanism is unclear. In this study, time-lapse recording revealed that human haploid parthenotes (HPs) undergo self-diploidization via failed cytokinesis (FC) and endomitosis (EM). The frequencies of FC/EM were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells Research
Share to Prenatal Screening and Diagnostics
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28652594
DOI: 10.1038/s41598-017-04602-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Self-diploidization of human haploid parthenogenetic embryos through the Rho pathway regulates endomitosis and failed cytokinesisPMID 28652594Read ↗

Self-Correction of Chromosomal Abnormalities in Human Preimplantation Embryos and Embryonic Stem CellsSemantic proximity Read ↗

Totipotency and lineage segregation in the human embryoSemantic proximity Read ↗

Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocystsSemantic proximity Read ↗

Low nucleus to cytoplasmic ratio compromises cytokinesis, genome stability and development in haploid embryonic cellsSemantic proximity Read ↗

Do human embryos have the ability of self-correction?Semantic proximity Read ↗

Arrested Cells/Cellular Debris Expelled from Blastocysts Is Self-Correction Phenomenon During Early Embryonic DevelopmentSemantic proximity Read ↗

Fundamental differences in endoreplication in mammals and <i>Drosophila</i> revealed by analysis of endocycling and endomitotic cellsSemantic proximity Read ↗

The first mitotic division of human embryos is highly error proneSemantic proximity Read ↗

Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosisSemantic proximity Read ↗

Endomitosis of Human Megakaryocytes Are Due to Abortive MitosisSemantic proximity Read ↗

Failure to recombine is a common feature of human oogenesisSemantic proximity Read ↗

Functional stability of the second mitotic spindle in blastomeres and its association with multinucleation repairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.