Article
A gene for congenital, recessive deafness DFNB3 maps to the pericentromeric region of chromosome 17.
Nature genetics - 1 Jan 1995
Friedman T B, Liang Y, Weber J L, Hinnant J T, Barber T D, Winata S, Arhya I N, Asher J H
Abstract excerpt
Two percent of the residents of Bengkala, Bali, have profound, congenital, neurosensory, nonsyndromal deafness due to an autosomal recessive mutation at the DFNB3 locus. We have employed a direct genome-wide disequilibrium search strategy, allele-frequency-dependent homozygosity mapping (AHM), and an analysis of historical recombinants to map DFNB3 and position the locus relative to flanking markers. DFNB3 maps...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Deafness
- Female
- Founder Effect
- Genes, Recessive
- Genetic Linkage
- Genetic Markers
- Humans