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Article

Further evidence for a third deafness gene within the DFNA2 locus.

American journal of medical genetics - 1 Apr 2002

Goldstein Jayne A, Lalwani Anil K

Abstract excerpt

DFNA2 is a complex locus. Two hearing loss genes have been identified at this site: GJB3, the gene that encodes the gap junction protein connexin 31, and KCNQ4, a voltage-gated potassium channel gene. A third gene has previously been postulated to explain the hearing loss in an Indonesian family linked to the region but devoid of mutation in either known gene (Van Hauwe et al. [1999: Nat Genet 21:263]). We have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11920835

Genes

GJB3
KCNQ4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Further evidence for a third deafness gene within the DFNA2 locus.PMID 11920835Read ↗

Linkage analysis of progressive hearing loss in five extended families maps the DFNA2 gene to a 1.25-Mb region on chromosome 1p.Semantic proximity Read ↗

Gene localization in a Chinese family with autosomal dominant non-syndromic deafness.Semantic proximity Read ↗

Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families.Semantic proximity Read ↗

Mapping of a new autosomal dominant non-syndromic hearing loss locus (DFNA43) to chromosome 2p12.Semantic proximity Read ↗

Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.Semantic proximity Read ↗

Refined localization and two additional linked families for the DFNA10 locus for nonsyndromic hearing impairment.Semantic proximity Read ↗

A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3.Semantic proximity Read ↗

DFNB68, a novel autosomal recessive non-syndromic hearing impairment locus at chromosomal region 19p13.2.Semantic proximity Read ↗

Localization of a novel autosomal recessive non-syndromic hearing impairment locus DFNB55 to chromosome 4q12-q13.2.Semantic proximity Read ↗

Mapping of a novel autosomal recessive nonsyndromic deafness locus (DFNB46) to chromosome 18p11.32-p11.31.Semantic proximity Read ↗

Fine mapping of autosomal dominant nonsyndromic hearing impairment DFNA21 to chromosome 6p24.1-22.3.Semantic proximity Read ↗

Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunctionSemantic proximity Read ↗

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