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Article

Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase.

The Journal of biological chemistry - 3 Apr 1998

Mazza C, Breton R, Housset D, Fontecilla-Camps J C

Abstract excerpt

Type 1 17beta-hydroxysteroid dehydrogenase (17beta-HSD1), a member of the short chain dehydrogenase reductase (SDR) family, is responsible for the synthesis of 17beta-estradiol, the biologically active estrogen involved in the genesis and development of human breast cancers. Here, we report the crystal structures of the H221L 17beta-HSD1 mutant complexed to NADP+ and estradiol and the H221L mutant/NAD+ and a...

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Identifiers

PMID: 9525918
DOI: 10.1074/jbc.273.14.8145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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