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Article

The second ETV6 allele is not necessarily deleted in acute leukemias with a ETV6/ABL fusion.

Genes, chromosomes & cancer - 1 Mar 1998

Hannemann J R, Healy L E, Ridge S A, Wiedemann L M

Abstract excerpt

The ETV6 (TEL) locus at chromosome band 12p 13 is a major site of translocations in acute leukemia, particularly in childhood acute lymphoblastic leukemia (ALL). In cases with translocations involving ETV6, the normal ETV6 allele is often deleted. In addition, loss of heterozygosity of ETV6 is frequently observed in childhood'ALL. Thus, it has been suggested that ETV6 may have an anti-oncogenic role to play, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9523202
DOI: 10.1002/(sici)1098-2264(199803)21:3<256::aid-gcc11>3.0.co;2-n

Genes

ETV6
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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The second ETV6 allele is not necessarily deleted in acute leukemias with a ETV6/ABL fusion.PMID 9523202Read ↗

Molecular cytogenetic and clinical findings inETV6/ABL1-positive leukemiaSemantic proximity Read ↗

Acute leukemias with <i>ETV6/ABL1</i> (<i>TEL/ABL</i>) fusion: Poor prognosis and prenatal originSemantic proximity Read ↗

Expression profile of wild-type ETV6 in childhood acute leukaemia.Semantic proximity Read ↗

Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model.Semantic proximity Read ↗

The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and Other Hematopoietic Cancers.Semantic proximity Read ↗

Detection of ETV6 gene rearrangements in adult acute lymphoblastic leukemia.Semantic proximity Read ↗

Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia.Semantic proximity Read ↗

ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic LeukaemiaSemantic proximity Read ↗

Variant of ETV6/ABL1 gene is associated with leukemia phenotype.Semantic proximity Read ↗

Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case.Semantic proximity Read ↗

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid LeukemiaSemantic proximity Read ↗

Modeling the evolution of ETV6-RUNX1–induced B-cell precursor acute lymphoblastic leukemia in miceSemantic proximity Read ↗

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