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Article

Slow ligand-induced conformational switch increases the catalytic rate in Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase.

Molecular bioSystems - 1 May 2015

Roy Sourav, Karmakar Tarak, Prahlada Rao Vasudeva S, Nagappa Lakshmeesha K, Balasubramanian Sundaram, Balaram Hemalatha

Abstract excerpt

P. falciparum (Pf) hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) exhibits a unique mechanism of activation where the enzyme switches from a low activity (unactivated) to a high activity (activated) state upon pre-incubation with substrate/products. Xanthine phosphoribosylation by unactivated PfHGXPRT exhibits a lag phase, the duration of which reduces with an increase in concentration of the...

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PMID: 25824378
DOI: 10.1039/c5mb00136f

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