Article
Creutzfeldt-Jakob disease in a husband and wife.
Neurology - 1 Mar 1998
Brown P, Cervenáková L, McShane L, Goldfarb L G, Bishop K, Bastian F, Kirkpatrick J, Piccardo P, Ghetti B, Gajdusek D C
Abstract excerpt
A 53-year-old man died of sporadic Creutzfeldt-Jakob disease (CJD) after a 1.5-year clinical course. Four and a half years later, his then 55-year-old widow died from CJD after a 1-month illness. Both patients had typical clinical and neuropathologic features of the disease, and pathognomonic proteinase-resistant amyloid protein ("prion" protein, or PrP) was present in both brains. Neither patient had a family...
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