Article
First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation.
Journal of neuropathology and experimental neurology - 1 Sept 2008
Webb Thomas E F, Pal Suvankar, Siddique Durrenajaf, Heaney Dominic C, Linehan Jacqueline M, Wadsworth Jonathan D F, Joiner Susan, Beck Jon, Wroe Stephen J, Stevenson Valerie, Brandner Sebastian, Mead Simon, Collinge John
Abstract excerpt
Sibling concurrence of pathologically confirmed prion disease has only been reported in association with pathogenic mutation of the prion protein gene (PRNP). Here, we report 2 siblings with classic neuropathologic features of sporadic Creutzfeldt-Jakob disease unexplained by PRNP mutation or known risk factors for iatrogenic transmission of prion infection. Possible explanations include coincidental occurrence,...
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