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Article

Relation of HFE gene mutations, high iron stores and early onset coronary artery disease.

The Canadian journal of cardiology - 1 Feb 1998

Nassar B A, Zayed E M, Title L M, O'Neill B J, Bata I R, Kirkland S A, Dunn J, Dempsey G I, Tan M H, Johnstone D E

Abstract excerpt

OBJECTIVE: To determine the impact of mutations in the HFE gene (human leukocyte antigen H) on predisposition to coronary artery disease (CAD) in patients not diagnosed with hereditary hemochromatosis. BACKGROUND: Elevated iron stores can predispose to acute myocardial infarction. Two mutations (C282Y and H63D) in the novel major histocompatibility complex (MHC) class 1 gene HFE were found in most patients with...

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Source

Identifiers

PMID: 9520858

Genes

CAD
HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Iron stores and HFE genotypes are not related to increased risk of first-time myocardial infarction: a prospective nested case-referent study.Semantic proximity Read ↗

Relation of genetic polymorphisms of apolipoprotein E, angiotensin converting enzyme, apolipoprotein B-100, and glycoprotein IIIa and early-onset coronary heart disease.Semantic proximity Read ↗

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