Article
Association between HFE mutations and acute myocardial infarction: a study in patients from Northern and Southern Italy.
Blood cells, molecules & diseases - 1 Jan 2000
Candore Giuseppina, Balistreri Carmela Rita, Lio Domenico, Mantovani Vilma, Colonna-Romano Giuseppina, Chiappelli Martina, Tampieri Cecilia, Licastro Federico, Branzi Angelo, Averna Maurizio, Caruso Marco, Hoffmann Enrico, Caruso Calogero
Abstract excerpt
There is interest in the role of iron in age-related diseases such as atherosclerosis. Tissue iron deposition could be harmful, because Fe(2+) can react with H(2)O(2) to form OH(-) radicals and Fe(2+) can react with O(2) to form reactive oxygen species. Free radicals react with cell membranes and cell organelles and could lead to the development of atherosclerosis by initiating lipid peroxidation. Hereditary...
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