Reduced fertility in female mice lacking copper-zinc superoxide dismutase.

Abstract excerpt

Copper-zinc superoxide dismutase (CuZn-SOD) is believed to play a major role in the first line of antioxidant defense by catalyzing the dismutation of superoxide anion radicals to form hydrogen peroxide and molecular oxygen. Recent studies have shown that missense mutations in this gene contribute, evidently through a gain-of-function mechanism, to about 20% of familial amyotrophic lateral sclerosis. To define...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Fertility
• Share to Mice
• Share to Mice, Knockout