Article
Male reproductive phenotype alterations in heterozygous β-globin gene knockout thalassemia (BKO) mice as a model for β-thalassemia patients.
Scientific reports - 10 Feb 2025
Aiemongkot Suparada, Ruschadaariyachat Sukanya, Changsangfa Chinarat, Nuamsee Khanita, Viwatpinyo Kittikun, Chaichompoo Pornthip, Svasti Saovaros, Buranaamnuay Kakanang
Abstract excerpt
Heterozygous β-globin gene knockout thalassemia (BKO) mice derived from C57BL/6 wild-type (WT) mice have phenotypic of β-thalassemia (BT) and have been widely used for studying this disease except reproductive disorders. The present study determined whether male BKO mice recapitulate reproductive problems as BT men. Mice were randomly assigned into groups depending on the genotype (WT vs. BKO) and intervention...
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