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Article

Impaired Fertilizing Ability of Superoxide Dismutase 1-Deficient Mouse Sperm During In Vitro Fertilization1

30 Aug 2012

Abstract excerpt

The oxidative modification of gametes by a reactive oxygen species is a major deleterious factor that decreases the successful rate of in vitro fertilization. Superoxide dismutase 1 (SOD1) plays a pivotal role in antioxidation by scavenging the superoxide anion, and its deficiency causes infertility in female mice, but the significance of the enzyme in male mice remains unclear. In the present study, we...

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PMID: 22933517
DOI: 10.1095/biolreprod.112.102129

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