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A genome scanning approach to assess the genetic effects of radiation in mice and humans.

Radiation research - 1 Apr 2004

Asakawa Jun-ichi, Kuick Rork, Kodaira Mieko, Nakamura Nori, Katayama Hiroaki, Pierce Donald, Funamoto Sachiyo, Preston Dale, Satoh Chiyoko, Neel James V, Hanash Samir

Abstract excerpt

We used Restriction Landmark Genome Scanning (RLGS) to assess, on a genome-wide basis, the mutation induction rate in mouse germ cells after radiation exposure. Analyses of 1,115 autosomal NotI DNA fragments per mouse for reduced spot intensity, indicative of loss of one copy, in 506 progeny derived from X-irradiated spermatogonia (190, 237 and 79 mice in 0-, 3-, and 5-Gy groups, respectively), permitted us to...

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PMID: 15038760
DOI: 10.1667/rr3146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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