Article
Allelic losses on chromosome 4 suggest the existence of a candidate tumor suppressor gene region of about 0.6 cM in gamma-radiation-induced mouse primary thymic lymphomas.
Oncogene - 1 Feb 1996
Santos J, Pérez de Castro I, Herranz M, Pellicer A, Fernández-Piqueras J
Abstract excerpt
Mouse chromosome 4 was investigated to assess the involvement of tumor suppressor genes in primary thymic lymphomas induced by gamma-irradiation. PCR analysis using microsatellite DNA polymorphic markers was performed in F1 animals generated from a cross between the strains C57BL/6J and RF/J. Mic...
Topics
- Alleles
- Animals
- Base Sequence
- Chromosome Deletion
- Chromosome Mapping
- Crosses, Genetic
- DNA Primers
- DNA, Satellite
- Female
- Gamma Rays
- Genes, Tumor Suppressor
- Genetic Markers
- Lymphoma
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Molecular Sequence Data