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Development of Improved Adenosine Deaminase Retroviral Vectors

1 Mar 1998

Abstract excerpt

A series of adenosine deaminase (ADA) retroviral vectors were designed and constructed with the goal of improved performance over the PA317/LASN vector currently used in clinical trials. First, the bacterial selectable-marker neomycin phosphotransferase (neo) gene was removed to create a "simplified" vector. Second, the Moloney murine leukemia virus long terminal repeat (LTR) promoter used for ADA expression was...

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PMID: 9499026
DOI: 10.1128/jvi.72.3.1769-1774.1998

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