Article
Expression of human glucocerebrosidase in murine macrophages: identification of efficient retroviral vectors.
Experimental hematology - 1 Aug 1994
Freas-Lutz D L, Correll P H, Dougherty S F, Xu L, Pluznik D H, Karlsson S
Abstract excerpt
Gaucher's disease is an autosomal recessive disorder characterized by a functional deficiency in beta-glucocerebrosidase enzymatic activity and the resultant accumulation of the glycolipid glucocerebroside in macrophages. Due to the nature of the affected cells, Gaucher's disease is an excellent...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Blotting, Western
- Cell Differentiation
- DNA Probes
- DNA, Neoplasm
- DNA, Viral
- Gaucher Disease
- Gene Expression Regulation, Enzymologic
- Genetic Vectors
- Glucosylceramidase
- Humans
- Interleukin-6
- Leukemia, Myeloid
- Macrophages
- Mice
- Molecular Sequence Data