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Article

Lack of multiple dosing effect of sertindole on the pharmacokinetics of alprazolam in healthy volunteers.

Psychopharmacology - 1 Feb 1998

Wong S L, Locke C, Staser J, Granneman G R

Abstract excerpt

The effect of sertindole (a new selective antipsychotic compound) on the pharmacokinetic disposition of alprazolam was investigated. Fourteen subjects who completed the study received a single 1 mg dose of alprazolam without or with concomitant sertindole 12 mg daily. Coadministration of sertindole and alprazolam led to a half-hour decrease (P < 0.05) in mean Tmax value (alone: 1.2 h, in combination: 0.7 h) and a...

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Identifiers

PMID: 9498726
DOI: 10.1007/s002130050505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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