Article
Refinement of the commonly deleted segment in myeloid leukemias with a del(20q).
Genes, chromosomes & cancer - 1 Feb 1998
Wang P W, Iannantuoni K, Davis E M, Espinosa R, Stoffel M, Le Beau M M
Abstract excerpt
A deletion of the long arm of chromosome 20 [del(20q)] is a recurring abnormality in a wide spectrum of myeloid disorders. Loss of genetic material from 20q may confer a proliferative advantage to myeloid cells, possibly through loss of function of a tumor suppressor gene. Previously, we analyzed leukemia cells from 19 patients with a del(20q) by fluorescence in situ hybridization (FISH) and identified a segment...
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