Article
A detailed physical and transcriptional map of the region of chromosome 20 that is deleted in myeloproliferative disorders and refinement of the common deleted region.
Genomics - 1 May 1998
Bench A J, Aldred M A, Humphray S J, Champion K M, Gilbert J G, Asimakopoulos F A, Deloukas P, Gwilliam R, Bentley D R, Green A R
Abstract excerpt
Acquired deletions of the long arm of chromosome 20 are the most common chromosomal abnormality seen in polycythemia vera and are also associated with other myeloid malignancies. Such deletions are believed to mark the site of one or more tumor suppressor genes, loss of which perturbs normal hematopoiesis. A common deleted region (CDR) has previously been identified on 20q. We have now constructed the most...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.