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Article

Forskolin and methotrexate induce an intermediate trophoblast phenotype in cultured human choriocarcinoma cells.

American journal of obstetrics and gynecology - 1 Jan 1991

Taylor R N, Newman E D, Chen S A

Abstract excerpt

The human placenta and its associated membranes are vital to the maintenance, nutrition, and protection of the developing fetus. During placental development some cytotrophoblasts give rise to the chorionic membrane whereas others fuse to form a differentiated syncytium of cells that are responsible for placental protein and steroid hormone production. The mechanisms involved in the differentiation of the...

Topics

Cell Differentiation
Cell Nucleus
Choriocarcinoma
Colforsin
Cytoplasm
Endocrine Glands
Gene Expression Regulation
Humans
Methotrexate
Phenotype
Placental Hormones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trophoblasts

Tumor Cells, Cultured

Source

Identifiers

PMID: 1986609
DOI: 10.1016/0002-9378(91)90654-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1986609-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Forskolin and methotrexate induce an intermediate trophoblast phenotype in cultured human choriocarcinoma cells.PMID 1986609Read ↗

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Trophoblast Cell Fusion and Differentiation Are Mediated by Both the Protein Kinase C and A PathwaysSemantic proximity Read ↗

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Identification of a Stress-Induced Protein During Human Trophoblast Differentiation by Differential Display Analysis1Semantic proximity Read ↗

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