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Article

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

9 Feb 2010

Abstract excerpt

BACKGROUND: Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol. Lactate dehydrogenase-A (LDH-A) is one of the predominant isoforms of LDH expressed in breast tissue, which controls the conversion of pyruvate to lactate and plays an important...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20144215
DOI: 10.1186/1476-4598-9-33

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