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Article

Evidence for in vivo ribosome recycling, the fourth step in protein biosynthesis.

The EMBO journal - 16 Feb 1998

Janosi L, Mottagui-Tabar S, Isaksson L A, Sekine Y, Ohtsubo E, Zhang S, Goon S, Nelken S, Shuda M, Kaji A

Abstract excerpt

Ribosome recycling factor (RRF) catalyzes the fourth step of protein synthesis in vitro: disassembly of the post-termination complex of ribosomes, mRNA and tRNA. We now report the first in vivo evidence of RRF function using 12 temperature-sensitive Escherichia coli mutants which we isolated in this study. At non-permissive temperatures, most of the ribosomes remain on mRNA, scan downstream from the termination...

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Identifiers

PMID: 9463391
DOI: 10.1093/emboj/17.4.1141
PMCID: PMC1170462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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