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Article

Regulation of the MDR1 promoter by cyclic AMP-dependent protein kinase and transcription factor Sp1.

International journal of oncology - 1 Feb 1998

Rohlff C, Glazer R I

Abstract excerpt

The expression of multidrug-resistance (MDR) in breast carcinoma cell line MCF-7/ADR50 is primarily dependent on the transcriptional activation of the MDR1 gene. We now report that MDR in this cell line is partially reversed by the type I cAMP-dependent protein kinase (PKA) inhibitor, 8-Cl-cAMP....

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Source

Identifiers

PMID: 9458366
DOI: 10.3892/ijo.12.2.383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9458366-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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