Automated nucleotide sequencing reveals substantial disparity between the HLA-A2 genes of bone marrow transplant recipients and donors.

doi:10.1016/s0198-8859(97)00106-7

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Article

Automated nucleotide sequencing reveals substantial disparity between the HLA-A2 genes of bone marrow transplant recipients and donors.

Human immunology - 1 Jan 2000

Szmania S, Keever-Taylor C, Baxter-Lowe L A

Abstract excerpt

HLA disparity is associated with immunological complications after bone marrow transplant and it has been demonstrated that a single amino acid substitution can dramatically alter the function or allorecognition of an HLA molecule. Current serological methods for typing Class I HLA do not disting...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Bone Marrow Transplantation
Gene Frequency
Genes, MHC Class I
HLA-A2 Antigen
Histocompatibility Testing
Humans
Sequence Analysis, DNA

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