Article
Inhibition of endosome fusion by wortmannin persists in the presence of activated Rab5.
Molecular biology of the cell - 1 Feb 1998
Jones A T, Mills I G, Scheidig A J, Alexandrov K, Clague M J
Abstract excerpt
Rab5-dependent endosome fusion is sensitive to the phosphoinositide 3-kinase inhibitor, wortmannin. It has been proposed that phosphoinositide 3-kinase activity may be required for activation of rab5 by influencing its nucleotide cycle such as to promote its active GTP state. In this report we demonstrate that endosome fusion remains sensitive to wortmannin despite preloading of endosomes with stimulatory levels...
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