Article
A combination of granulocyte-colony-stimulating factor (G-CSF) and plerixafor mobilizes more primitive peripheral blood progenitor cells than G-CSF alone: results of a European phase II study.
Cytotherapy - 1 Jan 2009
Fruehauf Stefan, Veldwijk Marlon Romano, Seeger Timon, Schubert Mario, Laufs Stephanie, Topaly Julian, Wuchter Patrick, Dillmann Falk, Eckstein Volker, Wenz Frederik, Goldschmidt Hartmut, Ho Anthony Dick, Calandra Gary
Abstract excerpt
BACKGROUND AIMS: Previous studies in xenograft models have shown that human peripheral blood progenitor cells (PBPC) mobilized with the CXCR4 antagonist plerixafor (AMD3100) have a higher bone marrow (BM) reconstitution potential than granulocyte-colony-stimulating factor (G-CSF)-mobilized PBPC. METHODS: PBPC obtained during G-CSF-supported mobilization before and after a supplementary administration of AMD3100...
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