The role of rosetting in the multiplication of <i>Plasmodium falciparum</i>: rosette formation neither enhances nor targets parasite invasion into uninfected red cells

Abstract excerpt

The effect of rosette formation on the multiplication in vitro of Plasmodium falciparum was studied in order to establish whether rosetting acts as a major virulence factor in the pathogenesis of severe malaria by facilitating invasion of uninfected red cells. Invasion rates for rosetting (R+) and non-rosetting (R-) parasites selected from the same clone, PA1, of P. falciparum were similar over a range of...

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