Article
Improved in vitro culture of Plasmodium falciparum permits establishment of clinical isolates with preserved multiplication, invasion and rosetting phenotypes.
PloS one - 1 Jan 2013
Ribacke Ulf, Moll Kirsten, Albrecht Letusa, Ahmed Ismail Hodan, Normark Johan, Flaberg Emilie, Szekely Laszlo, Hultenby Kjell, Persson Kristina E M, Egwang Thomas G, Wahlgren Mats
Abstract excerpt
To be able to robustly propagate P. falciparum at optimal conditions in vitro is of fundamental importance for genotypic and phenotypic studies of both established and fresh clinical isolates. Cryo-preserved P. falciparum isolates from Ugandan children with severe or uncomplicated malaria were investigated for parasite phenotypes under different in vitro growth conditions or studied directly from the peripheral...
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